“Organs-on-a-chip” as models for investigating biological processes on microfluidic chips have the potential to replace animal experiments in clinical research. For example, drug tests can be carried out on human cells, which not only eliminates the problem of transferability from animals to humans, but also potentially allows the tests to be tailored to the tumor tissue of individual patients. The aim of the ZIM project “VascuTISS” is to develop a modular and scalable chip technology for the dynamic cultivation of tissue models. In particular, a platform system in the form of a vascularized microfluidic chip is to be developed that is suitable for the standardized production of vascularized tissue models. The vascular networks produced by cell culture are to serve as a standardized and marketable basic module for pharmacological research into tumor invasion and migration as well as the interfaces between tissue and blood vessels. These vascularized, multicellular and complex tissue models and interfaces should provide more meaningful results in terms of in vitro testing of drugs and toxins than conventional, commercially available systems due to their biomimetic form.